In 1991, Warren G formed the group 213 with Nate Dogg and Snoop Dogg. In 1992, Warren G introduced the group to his half brother Dr. Dre. Dr. Dre was impressed and signed Snoop Dogg to his and Suge Knight's record company, Death Row Records. Thus, 213 broke up before releasing any records, and the three artists pursued separate careers. Even though Death Row Records did not sign Warren G, his career began with some contributions to Dr. Dre's album The Chronic, released 1992. Warren G was a regular contributor to many Death Row albums.

In 1993, Warren G produced the track Indo Smoke featuring himself, Nate Dogg, and Mista Grimm.

Warren G's debut album Regulate... G Funk Era was released in 1994 on Def Jam, featured the hit "Regulate" which samples Michael McDonald's classic hit, "Black. White.. in March 22, Warren G has made a song called "Mr. President", adressing the 2008 presidential candidate race and encourages everyone to vote.

He also appeared in Celebrity Rap Superstar as a mentor.