Manousakis gained his footing in live theater while at Columbia College in Chicago, where he studied composition with Gustavo Leone before returning to study with Tim Ward and Andreas Mniestris at the Ionian University in Corfu, Greece. Prior to his sojourn in Chicago, Manousakis was deeply engaged in both independent avant-garde theater and in the popular theater of his native country.
He is a co founder of ElectroMediaWorks, and a member of the Medea Electronique synergy of Artist.